1491 (MCDXCI) was a common year.
1491 may also refer to:
- 1491 (musical), 1969 musical by Meredith Willson
 - 1491: New Revelations of the Americas Before Columbus, 2005 non-fiction book by American author Charles C. Mann
 - 1491 Balduinus, outer main-belt asteroid
 - 1491s, Native America sketch comedy troupe
 
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