Singles
2018 Samarkand Challenger
Champion	Luca Vanni
Runner-up	Mario Vilella Martínez
Score	6–4, 6–4

Adrián Menéndez Maceiras was the defending champion but chose not to defend his title.

Luca Vanni won the title after defeating Mario Vilella Martínez 6–4, 6–4 in the final.

Seeds

Draw

Finals

	Semifinals							Final
		Luca Vanni	6	6
	4	Uladzimir Ignatik	3	3
									Luca Vanni	6	6
									Mario Vilella Martínez	4	4
	3	Nikola Milojević	2	4
		Mario Vilella Martínez	6	6

Top half

	First round							Second round							Quarterfinals							Semifinals
	1/WC	D Istomin	63	4
		P Cachin	77	6					P Cachin	6	4	64
		L Vanni	6	6					L Vanni	4	6	77
		Carlos Boluda-Purkiss	0	1												L Vanni	6	6
		A Šetkić	77	61	6										8	T-h Yang	2	4
	WC	S Fayziev	64	77	3				A Šetkić	2	3
	WC	F Dustov	1	3				8	T-h Yang	6	6
	8	T-h Yang	6	6																			L Vanni	6	6
	4	U Ignatik	6	6																		4	U Ignatik	3	3
		R Ortega Olmedo	2	4				4	U Ignatik	6	65	6
	Q	M Peña López	6	6				Q	M Peña López	4	77	1
	SE	S Betov	1	1											4	U Ignatik	6	6
		D Muñoz de la Nava	6	6											5	L Harris	3	3
		A Basso	2	1					D Muñoz de la Nava	77	5	63
	WC	J Karimov	3	3				5	L Harris	64	7	77
	5	L Harris	6	6

Bottom half

	First round							Second round							Quarterfinals							Semifinals
	6	A Nedovyesov	4	4
		M Zekić	6	6					M Zekić	6	6
	Q	R Safiullin	77	6				Q	R Safiullin	1	4
		T Gabashvili	64	4												M Zekić	2	1
		I Gakhov	7	77											3	N Milojević	6	6
		Patricio Heras	5	65					I Gakhov	3	4
	Q	S Fomin	0	0				3	N Milojević	6	6
	3	N Milojević	6	6																		3	N Milojević	2	4
	7	E Gerasimov	7	68	4																		M Vilella Martínez	6	6
		M Vilella Martínez	5	710	6				M Vilella Martínez	6	5	6
		JC Aragone	79	77					JC Aragone	4	7	0
		E Karlovskiy	67	65												M Vilella Martínez	5	6	6
		F Horanský	6	4	4										2	A Balázs	7	4	4
	Q	S Balaji	0	6	6			Q	S Balaji	65	63
		C Rodríguez	4	2				2	A Balázs	77	77
	2	A Balázs	6	6

References

• Main Draw
• Qualifying Draw