Al-Ghafiqi is a surname. Notable people with the surname include:
- Abdul Rahman Al Ghafiqi, a governor of Al-Andalus
- Muhammad ibn Aslam Al-Ghafiqi, a 12th-century Andalusian oculist and author of The Right Guide to Ophthalmology
- Abū Jaʿfar al-Ghāfiqī, a 12th-century Andalusian Arab botanist, pharmacologist, physician
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