Apalachee may refer to:
People
- Apalachee people, historical tribe from the Florida Panhandle
 
Places
- Apalachee, Georgia, an unincorporated community
 - Apalachee Bay, a bay of the Gulf of Mexico
 - Apalachee Province, an area of what is now the Florida Panhandle historically inhabited by the Apalachee
 - Apalachee River (Alabama), a river in the U.S. state of Alabama
 - Apalachee River (Georgia), a river in the U.S. state of Georgia
 
Other
- Apalachee (horse), a thoroughbred racehorse
 - Apalachee language, an extinct Muskogean language
 - Talimali Band of Apalachee Indians, a nonprofit organization in Louisiana
 
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