Borysyuk is a Ukrainian-language surname derived from the first name Boris. It may be Russified as Borisyuk. It may refer to:
- Ariel Borysiuk, Polish footballer
 - Mykhaylo Borysyuk, a Hero of Ukraine
 - Oleksandr Borysyuk, Ukrainian athlete
 - Sergey Borisyuk, a Hero of the Russian Federation
 
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