The molecular formula C15H16O5 (molar mass: 276.28 g/mol, exact mass: 276.099774 u) may refer to:
- Dihydromethysticin, a kavalactone found in the kava plant
- Lactucin, a bitter sesquiterpene lactone found in lettuce
- Vernolepin, a sesquiterpene lactone found in Vernonia amygdalina
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