Castiglioni is an Italian surname. People with this surname include:
- Giannino Castiglioni (1884–1971), Italian artist
 - Achille Castiglioni (1918–2002), Italian architect and industrial designer
 - Livio Castiglioni (1911–1979), Italian architect and industrial designer
 - Pier Giacomo Castiglioni (1913–1968), Italian architect and industrial designer
 
- Francesco Saverio Castiglioni (1761–1830), Pope Pius VIII
 - Goffredo da Castiglione / Godfrey Castiglioni (died 1241), Pope Celestine IV
 - St. Buono Castiglioni (818–822), Bishop of Milan
 - St. Honoratus Castiglioni (568–572), Bishop of Milan
 - Teresa Ciceri Castiglioni (1750–1821) was an Italian inventor, agronomist
 
- Arturo Castiglioni (1874–1952), Italian-American medical historian
 - Camillo Castiglioni (1879–1961), Austrian financier and banker
 - Consuelo Castiglioni, b. 1959, Chilean-Italian fashion designer
 - Luis Alberto Castiglioni Soria, former vice president of Paraguay
 - Niccolò Castiglioni (1932–1996), Italian composer and pianist
 
See also
- Palazzo Castiglioni (disambiguation)
 - The Castiglioni Brothers (film)
 - Castigliano
 - Castiglione (disambiguation)
 - Castiglione (surname)
 - Via Fratelli Castiglioni (street in Milan named after Achille, Livio, and Pier Giacomo Castiglioni)
 
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