Coomb is an alternate spelling of combe.
It may also refer to:
- Arthur Coomb (born 1929), English cricketer
 - Coomb (unit), a unit of measure by volume.
 - Coombs test, an aid to medical diagnosis.
 - Coomb Teak or Gmelina arborea, a medicinal tree.
 
See also
- Deeping Coomb, a fictional deep valley in The Lord of the Rings.
 - Coombe (disambiguation)
 - Combe (disambiguation)
 - Cwm (disambiguation)
 
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