David Sanders may refer to:
- William David Sanders (1951–1999), known as Dave Sanders, was a teacher killed during the Columbine High School massacre. Sanders is known for having helped to save the lives of a number of students and staff members prior to being fatally shot by the gunmen.
- David Sanders (baseball) (born 1979), baseball pitcher
- David Sanders (biologist), associate professor of biological sciences at Purdue University
- David J. Sanders (born 1975), member of the Arkansas State Senate
- David Sanders, the captain of FedEx Flight 705
- Davy Sanders, character in Alabama Moon
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