De la Roca is a surname. Notable people with the surname include:
- Antonio de la Roca, an Anglo-French Antarctic explorer
 - Joaquín Martínez de la Roca, a Spanish composer
 - Zack de la Rocha, an American rapper and singer
 
See also
- Castellfollit de la Roca, a region of Spain
 - La Roca de la Sierra, a region of Spain
 - Castillo de San Pedro de la Roca, a Cuban fortress
 - Della Rocca (disambiguation)
 - Roca (disambiguation)
 
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