Duff is a nickname of:

  • Duff Armstrong (1833–1899), American soldier successfully defended by Abraham Lincoln against the charge of murder
  • Duff Goldman (born 1974), star of Food Network's reality show Ace of Cakes
  • Duff Holbrook (1923–2015), American wildlife biologist, forester and outdoorsman
  • John Lowe (musician) (born 1942), English pianist for The Quarrymen, a forerunner of The Beatles
  • Duff McKagan (born 1964), bassist of Guns N' Roses and former bassist of Velvet Revolver
  • Duff Pattullo (1873–1956), Canadian politician, 22nd premier of British Columbia
  • Dufferin Roblin (1917–2010), Canadian businessman and politician
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