ESE or Ese may refer to:
Words
- Ēse, gods in Germanic paganism
 - Ese language, a language of Papua New Guinea
 - Ese (river), a river in the department of Corse-du-Sud, Corsica, France
 - Ese Mrabure-Ajufo (born 1992), Canadian football player
 
Abbreviations
- Early streamer emission
 - East-southeast, a compass direction (one of the eight "half-winds")
 - Easy Serving Espresso Pod
 - Ethical Sensory Extrovert
 - European School of Economics
 - European Society of Endocrinology
 - Exonic splicing enhancer
 - Exoskeletal engine
 - Extensible Storage Engine
 - Massachusetts Department of Elementary and Secondary Education
 
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