Ene or ENE may refer to:
Ene
- Ene (name), a given name and surname
 - Ene, a type of hydrocarbon involved in the Ene reaction and the Thiol-ene reaction
 - -ene, a suffix used in the names of certain organic compounds (alkenes)
 - Ene, Spanish abbreviation for January
 - Eñe, the Spanish name of the letter ñ
 - Ene River, in Peru
 
ENE
- East-northeast, a compass point and an intercardinal direction
 - Ee Nagaraniki Emaindhi, often abbreviated as ENE, 2018 Indian Telugu-language film
 - Empresa Nacional de Electricidade de Angola, former company of Angola
 - ENE, the IATA airport code for Ende Airport, serving Flores, Indonesia
 - ENE, NYSE ticker symbol for Enron, a defunct American energy company
 - Early neutral evaluation, a form of alternative dispute resolution aimed at reaching an early settlement
 - End-point network element, a type of network element found in computer and telecommunications networks
 - ENE, Emergent, Networked, Event-driven (ENE) process. Sometimes END
 
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