Flight 1 or Flight 001 is an airline flight number that has had multiple accidents and incidents. It may refer to:
- American Airways Flight 1 (1936), a Douglas DC-2 that crashed near Goodwin, Arkansas in 1936 en route from Memphis to Little Rock
- TWA Flight 1, a Douglas DC-2 that crashed in Pennsylvania en route from Newark to Los Angeles in 1936
- Northwest Airlines Flight 1, a Lockheed Super Electra that suffered a fire on board and crashed in Montana in 1939 coming from Minneapolis
- American Airlines Flight 1 (1941), a Douglas DC-3 that crashed near Lawrence Station, Ontario in 1941 en route from Buffalo to Detroit
- American Airlines Flight 1 (1962), a Boeing 707 that crashed after a rudder failure in 1962 just out of New York towards Los Angeles
- "Flight 1" (Mad Men), an episode of the television show Mad Men, centering in part on the American Airlines crash
- CSA Flight 001, a flight that crashed in Czechoslovakia in 1976
- Icelandic Airlines Flight 001, a Douglas DC-8 that crashed in Sri Lanka in 1978
- Qantas Flight 1, a flight that overran the runway in Bangkok in 1999
See also
- List of flights with flight number 1 according to carrier.
- Flight 901
- Flight 191
- Flight 101
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