Francis or Frank Cook may refer to:
- Francis Cook, 1st Viscount of Monserrate (1817–1901), British textile trader
 - Sir Francis Cook, 4th Baronet (1907–1978), British artist
 - Frank Cook (American football) (fl. 1892), American football coach
 - Frank Cook (American musician) (1942–2021), American drummer for the blues rock band Canned Heat
 - Frank Cook (Australian footballer) (1916–1973), Australian rules footballer
 - Frank Cook (Norwegian musician), Norwegian jazz musician and band leader
 - Frank Cook (politician) (1935–2012), British politician
 - Frank Cook (surgeon) (1888–1972), obstetric and gynaecological surgeon
 - Francis A. Cook (1843–1916), U.S. States Navy officer
 - Frank C. Cook IV (1963–2009), American ethnobotanist, humanitarian and educator
 
See also
- Francis Cooke (disambiguation)
 - Frank Cooke (disambiguation)
 - Frances Crook, chief executive of the Howard League for Penal Reform
 - Cook (surname)
 
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