Look up guayo in Wiktionary, the free dictionary.
A guayo is a Cuban percussion instrument. It may also refer to:
- A grater, in the Caribbean
 - Guayo Cedeño (born 1974), Honduran musician
 
Places
- Guayo River, Puerto Rico
 - Guayo, Adjuntas, Puerto Rico, a barrio in Adjuntas, Puerto Rico
 - Guayos, town in Cuba
 
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