HCB may refer to:
- Hackbridge railway station, a railway station in South London
- Hampshire Cricket Board, the governing body for cricket in Hampshire, England
- Hamptons Collegiate Baseball, a summer baseball organization in New York State
- HCB (classification), a paralympic cycling classification
- HCB South Tyrol, an ice hockey club in Italy
- Henri Cartier-Bresson, a French photographer considered to be the father of modern photojournalism
- Hexachlorobenzene, a toxic fungicide formerly used as a seed treatment
- Homemade chemical bomb, an explosive device that can be made easily from volatile household chemicals
- Hydrocarbonoclastic bacteria, a form of oil biodegrader
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