HS or Hs can stand for:
Businesses and brands
- HS Produkt, a Croatian firearms manufacturer
 - Helsingin Sanomat, a newspaper in Finland
 - Hawker Siddeley, aircraft manufacturing group
 - Henschel & Son, in aircraft prefixes; e.g., Hs 117
 - Head & Shoulders or H&S, a shampoo brand
 - Harris Scarfe and HS Home, a chain of Australian department stores
 
Science and technology
Chemistry
- Hassium, symbol Hs, a chemical element
 - Bisulfide, HS−, a chemical compound derived from H2S
 - Mercapto radical, HS•, a radical molecule
 - Hun stuff (a World War I name for mustard gas)
 
Medicine
- hs, medical abbreviation for "hours of sleep"
 - h.s., medical abbreviation for the Latin phrase hora somni ("at bedtime")
 - Hereditary spherocytosis, a genetic disorder marked by hemolytic anemia
 - Hidradenitis suppurativa, a skin condition affecting apocrine sweat glands and hair follicles
 
Other uses in science and technology
- '.hs', the Haskell programming language's typical filename extension
 - Heat sink
 - Higman–Sims group, in mathematics
 - Hypothetical syllogism, a proof rule in classical logic
 - Horizon scanning, a method from futures studies
 
Vehicles
- Curtiss HS, an American patrol flying boat
 - Lexus HS, a Japanese compact hybrid sedan
 - MG HS, a Chinese-British compact SUV
 - YTHS HS, a Chinese unmanned aerial vehicle series
 
Other uses
- Harlem Spartans, a British hip hop collective
 - Harmonized System, the Harmonized Commodity Description and Coding System of tariff nomenclature
 - Sestertius, an ancient Roman coin
 - High school (secondary education)
 - Solar Hijri calendar (= Hijri Shamsi)
 - Holy Spirit
 - HS postcode area, covering the Outer Hebrides, Scotland
 - SS-Heimatschutz Slowakei (HS), a German paramilitary group in Slovakia during World War II
 - Thailand (aircraft registration prefix HS)
 
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