Huidobro is a surname. Notable people with the surname include:
- Eleuterio Fernández Huidobro (1942–2016), Uruguayan guerrilla fighter and politician
 - Gerardo Huidobro, Peruvian swimmer
 - Norma Huidobro
 - Pascual Ruiz Huidobro (1752–1813) Spanish colonial governor, active in Montevideo
 - Vicente Huidobro (1893–1948), Chilean poet
 - Zuleyma Huidobro (born 1978), Mexican politician
 
- Other uses
 
- Huidobro, populated place in Burgos Province, Spain
 - Villa Huidobro, populated place in Córdoba Province, Argentina
 
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