Kalugin is a Russian surname. Notable people with the surname include:
- Erik Kalugin (1937–2003), Soviet sprint canoer
 - Oleg Kalugin (born 1934), former Soviet KGB general
 - Oleg Vladimirovich Kalugin (born 1989), Russian football midfielder
 - Sergey Kalugin (born 1967), Russian musician, leader of the rock band Orgia Pravednikov
 
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