Kozyrev (masculine, Russian: Козырев) or Kozyreva (feminine, Russian: Козыревa) is a Russian surname. Notable people with the surname include:
- Andrey Kozyrev (born 1951), Russian politician
 - Lyubov Kozyreva (disambiguation), multiple people
 - Nikolai Aleksandrovich Kozyrev (1908-1983), Soviet astronomer and astrophysicist
 - Nikolai Ivanovich Kozyrev (1934-2021), Soviet and Russian diplomat
 - Yuri Kozyrev (born 1963), Russian photojournalist
 - Stanislav Kozyrev (born 1987), Russian footballer
 
See also
- 2536 Kozyrev, main-belt asteroid
 - Kozyrev (crater), lunar crater
 
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