This is a list of Mar Thoma Syrian Christians.
Evangelists and saintly persons
- Abraham Malpan, pioneering cleric of the Malankara Syrian Church
 - Iype Thoma Kathanar, pioneer cleric, & father of rationalist Abraham Kovoor
 - Sadhu Kochoonju Upadesi, preacher, poet and composer
 - Philipose Mar Chrysostom, prelate and the emeritus Metropolitan of the Malankara Mar Thoma Syrian Church
 - Easow Mar Timotheos Episcopa, episcopa (bishop) of the Mar Thoma Syrian Church
 - Anchal Achan, saint of Anchal
 - Abraham Mar Thoma, head of the Malankara Mar Thoma Syrian Church from 1944–1949
 - Juhanon Mar Thoma, head of the Malankara Mar Thoma Syrian Church from 1949–1976
 - Alexander Mar Thoma, head of the Malankara Mar Thoma Syrian Church
 - Joseph Mar Thoma, XXIst Marthoma Metropolitan
 
Politics
- P. J. Kurien - former Deputy Chairman Rajya Sabha
 - Mathew T. Thomas - MLA (Tiruvalla)
 

Mathew Thomas
- Thomas Chandy - MLA (Kuttanad), former Minister for Public Transport (Kerala Government)
 

Thomas Chandy
- Madathilparampil Mammen Thomas - Governor of the Nagaland (from May 1990 to April 1992)
 - T. M. Varghese - freedom fighter and statesman
 - Thampan Thomas - MP of 8th Lok Sabha, Mavelikara Constituency
 - Rosamma Punnoose - First Pre-term Speaker of the Kerala Assembly
 - Titusji - the only Christian in a group of 78 marchers selected by Mahatma Gandhi to take part in the 1930 Dandi March, to break the salt law.
 - George Joseph - Indian independence activist
 
Literature

M. Thomas Mathew
- Kakkanadan, short story writer and novelist in the Malayalam language
 - K. M. Tharakan, critic, novelist, litterateur and educationalist
 - Meena Alexander, poet, scholar, and writer
 - Anna Sujatha Mathai, poet
 - Sarah Thomas, Malayalam language writer
 - Kuzhivelil Mathew, biblical scholar
 
Arts and media
- John Abraham (director) - Malayalam Director
 - Blessy - Film Director
 - John Abraham (actor) - Actor (Bollywood)
 - Meera Jasmine - National Award Winning Actress
 - Joy Mathew - Actor
 - Kailash, Film actor
 - Sandra Thomas - Film producer and actress
 - John Matthew Matthan - Director of Bollywood movie, Sarfarosh
 - Deepa Mariam - Singer
 
Science, humanities, sports, and public service
- K. T. Thomas (Justice) - Justice of the Supreme Court of India (1996–2002)
 
- T. K. Oommen - Economist
 - Pothan Joseph - Journalist
 - Sunnykutty Abraham - Journalist
 - Sunny Varkey - Entrepreneur
 - Perakath Verghese Benjamin - Indian physician and medical writer, Padma awardee, expert in tuberculosis treatment in India
 - M. O. Mathai - Private Secretary to India's first Prime Minister, Jawaharlal Nehru, popularly called as 'MAC' in political circles of that period
 - Benjamin Pulimood - Director/Principal of the Christian Medical College & Hospital, Vellore, Tamil Nadu, India
 - George Joseph - Scientist
 - Thomas Philipose - Only Mahavir Chakra holder from Kerala.
 
Marthoma Syrians by birth but stalwarts in other denominations
- P. C. John - Evangelist Kerala Brethren Church
 - Poykayil Johannan - was a Dalit activist, poet and founder of Prathyaksha Raksha Daiva Sabha or PRDS
 - Abraham Kovoor - Indian professor and rationalist, Founder of "Yukthi Vadhi Sangam"
 - K. V. Simon - Notable Malayalam Christian poet from Kerala and prominent leader of the Kerala Brethren movement.
 - K. P. Yohannan - founder and president of Gospel for Asia and Metropolitan Bishop of Believers Church
 
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