Route 205 or Highway 205 may refer to:

Canada

• Manitoba Provincial Road 205
• New Brunswick Route 205
• Newfoundland and Labrador Route 205
• Nova Scotia Route 205
• Prince Edward Island Route 205
• Quebec Route 205

China

• China National Highway 205

Costa Rica

• National Route 205

India

• National Highway 205 (India)

Japan

• Japan National Route 205

Thailand

• Thailand Route 205 (Suranarai Road)

United States

• Interstate 205
• Alabama State Route 205
• Connecticut Route 205
• Florida State Road 205 (former)
• Georgia State Route 205 (former)
• Indiana State Road 205
• Iowa Highway 205 (former)
• K-205 (Kansas highway)
• Kentucky Route 205
• Maine State Route 205
• M-205 (Michigan highway) (former)
• Montana Secondary Highway 205
• New Mexico State Road 205
• New York State Route 205
• North Carolina Highway 205
• Ohio State Route 205
• Oregon Route 205
• Pennsylvania Route 205 (former)
• Tennessee State Route 205
• Texas State Highway 205
  • Texas State Highway Loop 205
• Utah State Route 205 (former)
• Virginia State Route 205

Territories

• Puerto Rico Highway 205