Lou may refer to:
Personal name
- Lou (given name), a list of people and fictional characters
 - Lou (German singer)
 - Lou (French singer)
 - Lou (surname 娄), the 229th most common surname in China
 - Lou (surname 楼), the 269th most common surname in China
 
Arts and entertainment
- Lou (2010 film)
 - Lou (2017 film), a Pixar short
 - Lou (2022 film), a Netflix action thriller
 - Lou!, a French series of comic books created by Julien Neel
 - Lord of Ultima, a browser-based MMORTS game developed by EA
 
Other uses
- Lyon Olympique Universitaire, a rugby union team playing in the Top14 competition of France
 - Bowman Field (airport) (IATA airport code LOU), an airport in Louisville, Kentucky, USA
 - Lou Island of Papua New Guinea
 - Lou language (Austronesian) of Lou Island
 - Lou language (Torricelli)
 - Letter of understanding, a formal text that sums up the terms and understanding of a contract
 
See also
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