O'Hurley is a surname, and may refer to:
- Dermot O'Hurley (c. 1530–1584), Irish Roman Catholic archbishop of Cashel.
- John O'Hurley (born 1954), American actor, voice actor, and television personality.
- Raymond O'Hurley (1909–1970), Canadian politician.
See also
- Hurley (disambiguation)
- Hurley (surname)
- O'Herlihy (surname)
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