P80 may refer to:
Automobiles
- BMW P80, a family of Formula One engines
 - Toyota Starlet (P80), a Japanese car
 - Volvo P80 platform, a Swedish mid-size automobile platform
 - WM P80, a French prototype racing car
 
Other vehicles
- P80 (rocket stage), a rocket engine
 - INS Kavaratti (P80), a corvette of the Indian Navy
 - Lockheed P-80 Shooting Star, an American jet fighter
 - Pottier P.80, a French sport aircraft
 
Other uses
- Nikon Coolpix P80, a digital camera
 - P80, a national road of Latvia
 - Pestivirus NS3 polyprotein peptidase, an enzyme
 - p80, a subunit of the protein Katanin
 
See also
- Pistole 80, a military designation for the Glock pistol
 - Polymer80, an American firearms manufacturer
 
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