Pires is a Portuguese surname.
Pires may also refer to:
- Autódromo Fernanda Pires da Silva, race course in Estoril, Portugal
 - Music from Van-Pires, John Entwistle's last studio solo album
 - Pires (Monção), a village in Monção, Portugal
 - Pires do Rio Microregion, a region of south-central Goiás state, Brazil
 - Pires do Rio, municipality in Goiás state, Brazil
 - Ribeirão Pires, a municipality in the state of São Paulo, Brazil
 - Pires (Portuguese footballer) (born 1931), Portuguese football defender
 - Pires (Brazilian footballer) (born 1956), Brazilian football defensive midfielder
 
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