Pleydell may refer to:
- Edmund Pleydell, MP for Wootton Bassett
 - Edmund Morton Pleydell, MP for Dorchester and Dorset
 - Gabriel Pleydell (fl. 1519–c.1591), English politician
 - John Pleydell (1601–1693), English politician
 - Josiah Pleydell (c.1641–1707), Archdeacon of Chichester
 - William Pleydell, English lawyer and politician, brother of the above
 - Pleydell baronets
 
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