Santa Croce is Italian for 'Holy Cross' and may refer to:
- Santa Croce (Venice), one of the six sestieri (districts) of Venice, Italy.
 - The Pontifical University of the Holy Cross (Italian: Pontificia Università della Santa Croce) in Rome, Italy.
 - Many churches, including:
- Santa Croce, Florence, built 1294–1385 and the burial place of several notable Italians
 - Santa Croce della Foce, Gubbio, Umbria, built in the 13th century
 - Basilica di Santa Croce (Lecce), built 1549–1646
 - Santa Croce, Parma, built 1222–1666
 - Santa Croce, Padua, built 1737–1749
 - Santa Croce in Fossabanda, Pisa, built 1325–19th century
 - Santa Croce e San Bonaventura alla Pilotta, Rome, built 1625–19th century
 - Santa Croce in Gerusalemme, Rome, consecrated around 325
 - Santa Croce alla Lungara, Rome, consecrated 1619
 - Santa Croce degli Armeni, Venice, built 13th century, consecrated 1688
 - Santa Croce in Via Flaminia, Rome, built 1913, consecrated 1981
 
 
People
- House of Santacroce, a noble Roman family. To this belongs among others:
- Prospero Santacroce, 16th-century cardinal
 
 - Fabiano Santacroce (born 1986), Italian-Brazilian football player
 - Isabella Santacroce (born 1970), Italian novelist
 - Girolamo Santacroce, a 16th-century Italian sculptor and painter
 
Places
- Santa Croce sull'Arno, town in Tuscany
 - Santa Croce Camerina, town in Sicily
 
Villages
- Santa Croce di Magliano, a commune in Campobasso, Molise
 - Santa Croce di Roccaromana, a commune in Caserta, Campania
 - Santa Croce del Sannio, a commune in Benevento, Campania
 
See also
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