Thomas Greene may refer to:
- Sir Thomas Green (c. 1461–1506), grandfather of Katherine Parr, last wife of Henry VIII
 - Thomas Greene (governor) (1609–1651), Proprietary Governor of the colony of Maryland, 1647–1648/1649
 - Thomas Greene (bishop), Bishop of Ely, 1723–1738
 - Thomas Christopher Greene (born 1968), American novelist
 - Thomas M. Green Jr. (1758–1813), delegate to the United States Congress from Mississippi Territory
 - Thomas A. Greene (1827–1894), amateur geologist
 - Tom Greene (Florida politician) (born 1932), Florida state representative from 1963 to 1966, and state senator from 1966 to 1967
 - Thomas Greene (Iowa politician) (born 1949), American politician in the Iowa State Senate
 - Tom Greene (Louisiana politician) (born 1948), member of the Louisiana State Senate
 - Tom Greene (American football) (born 1938), American football quarterback and punter
 - Thomas Rea Greene (1904–1950), steamboat captain from Ohio
 - Thomas Greene (MP) (1790–1871), British Member of Parliament for Lancaster
 - Thomas McLernon Greene (1926–2003), American scholar of English literature
 - Thomas Garland Greene, Canadian painter
 - Fred Clifton (1844–1903), stage name of English opera singer and actor Thomas Huslea Greene
 
See also
- Tommy Greene (born 1967), former Major League Baseball pitcher
 - Thomas Green (disambiguation)
 - Tom Green (disambiguation)
 
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