Thomas Middleton (1580–1627) was an English playwright.
Thomas Middleton may also refer to:
- Thomas Middleton (died 1429), MP for Southampton
 - Thomas Myddelton (younger) (1586–1666), Welsh politician, parliamentarian soldier during the English Civil War
 - Thomas Middleton (Sussex) (1589–1662), English politician who sat in the House of Commons variously between 1640 and 1660
 - Sir Thomas Middleton (1654–1702), MP for Harwich
 - Thomas Middleton (1676–1715), MP for Essex
 - Thomas Fanshawe Middleton (bishop) (1769–1822), Anglican bishop in India
 - Thomas Cooke Middleton (1842–1923), American priest
 - Sir Thomas Hudson Middleton (1863–1943), Statute 12 Fellows of the Royal Society
 - Thomas Percy Middleton (1893–?), British flying ace of World War I
 - Thomas M. Middleton (born 1945), American politician from Maryland
 
See also
- Thomas Middleton Raysor (1895–1974), American literary scholar
 - Tom Middleton, English electronic recording artist
 - Tom Middleton (rower) (born 1976), British rower
 - Tom Middleton (Canadian singer), former Canadian pop singer
 - Thomas Myddelton (disambiguation)
 
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