Muller is a surname. Notable people with the surname include:
A–H
- A. Charles Muller (born 1953), translator
 - Bauke Muller (born 1962), Dutch bridge player
 - Bennie Muller (born 1938), Dutch footballer
 - Bill Muller (1965–2007), US journalist
 - Bobby Muller (born 1946), Vietnam veteran
 - Carl Muller (1935–2019), Sri Lankan Burgher writer, poet, and journalist
 - David E. Muller (1924–2008), American mathematician and computer scientist
 - Derek Muller (born 1982), science communicator
 - Dominique Muller (born 1949), French writer
 - Édouard Muller (painter) (1823–1876), Swiss-French painter
 - Édouard Muller (cyclist) (1919–1997), French road racing cyclist
 - Ellen Preis (Ellen Müller-Preis) (1912–2007), German-born Austrian fencer
 - Émile Muller (1915–1988), French politician
 - Filinto Muller (1900-1973), Brazilian politician
 - Franck Muller (born 1958), Swiss watchmaker
 - François Muller (1764–1808), French general of the French Revolutionary Wars
 - Frank Muller (1951–2008), Dutch audio book narrator and actor
 - Frans Muller (born 1960/61), Dutch businessman
 - Frederick Muller (1861–1946), American Medal of Honor recipient
 - Gary Muller (born 1964), South African tennis player
 - Germain Muller (1923–1994), French playwright, actor, poet, humourist, politician
 - Hendrik Pieter Nicolaas Muller (1859–1941), Dutch businessman, publicist, and diplomat
 - Henry J. Muller (1917-2022), American brigadier general
 - Henry J. Muller (CERDEC), American commanding general
 - Herbert J. Muller (1905–1980), American historian, academic, government official and author
 - Hermann Joseph Muller (1890–1967), US geneticist (Muller's ratchet) and educator
 - Muller (footballer, born 1986), Muller Santos da Silva, Brazilian football striker
 
J–Z
- Jacques Muller (politician) (born 1954), French politician
 - Jacques Léonard Muller (1749–1824), French army commander of the French Revolutionary Wars
 - Jean M. Muller (1925–2005), French structural engineer
 - Jim Muller, co-founder of Voice of the Faithful
 - Judy Muller, American journalist
 - Kirk Muller (born 1966), Canadian hockey player
 - Kyle Muller (born 1997), American baseball player
 - Lucien Muller (born 1934), French footballer and manager
 - Luke Muller (born 1996), American sailor and Olympian
 - Mae Muller (born 1997), English singer-songwriter
 - Mancow Muller (born 1966), American radio and television personality
 - Marcia Muller (born 1944), American mystery writer
 - Mary Ann Wilson Griffiths Müller (1819–1901) aka "Fémmina," New Zealand pamphleteer
 - Mervin E. Muller (1928–2018), American computer scientist
 - Oscar Muller (1957–2005), Argentine footballer
 - Peter Muller (Canadian football) (born 1951), Canadian football player
 - Peter Paul Muller (born 1965), Dutch actor
 - Pieter Muller (born 1969), South African rugby player
 - Ramon Muller (1935–1986), Argentine footballer
 - Richard A. Muller (born 1944), American physicist
 - Robert Muller (1923–2010), United Nations employee
 - Romeo Muller (1928–1992), American actor and writer
 - Scott Muller (canoeist) (born 1970), Panamanian canoer
 - Scott Muller (cricketer) (born 1971), Australian cricketer
 - Shulamith Muller (1922–1978). South African lawyer, communist, and anti-apartheid activist
 - Sophie Muller (born 1962), British music video director
 - Steven Muller (1927–2013), president of Johns Hopkins University
 - Victor Muller (born 1959), Dutch entrepreneur
 - Virginie Duby-Muller (born 1979), French politician
 - Yvan Muller (born 1969), French auto racing driver
 - Thomas Muller (born 1989), German football player for FC Bayern Munich
 
Fictional characters
- Caroline "Cathy" Muller, fictional character created by Tom Clancy, wife of Jack Ryan
 - Rudolfine Muller, a character from Strike Witches
 - Jake Muller, Albert Wesker's illegitimate son and protagonist of the video game Resident Evil 6
 - Jerry Muller, a character in the 1934 film The Man Who Changed His Name
 
See also
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